ITO Thailand Hygiene Blog

Sep 18 2023

Food Safety Aspects of Artificial Sweeteners

What are Artificial Sweeteners?

            Artificial sweeteners, also known as sugar substitutes, non-nutritive sweeteners, or high-intensity sweeteners, are artificially produced compounds utilised in place of sucrose (table sugar) to add sweetness to food and drinks. Due to their significantly higher sweetness than regular sugar, only a fraction of artificial sweeteners (200 to 20,000 times less) is required to achieve an equivalent level of sweetness. Since the caloric contribution of these sweeteners, when used in such small quantities, is insignificant, they are often referred to as non-nutritive (4).

            As of now, only six artificial sweeteners have been approved as food additives by the United States Food and Drug Administration (USFDA), including, Aspartame, Acesulfame-K (Acesulfame potassium), Saccharin, Sucralose, Neotame, and Advantame. Moreover, two additional sweeteners can be used as ‘Generally Recognised as Safe’ (GRAS), including certain Steviol Glycosides and Monk Fruit (2).

Benefits of Artificial Sweeteners

            There are several benefits of artificial sweeteners (3), such as

            •Beneficial option for individuals with diabetes – as artificial sweeteners provide a valuable solution for people with diabetes who desire sweet flavours. Artificially sweetened beverages offer a convenient alternative for individuals who regularly consume soft drinks and wish to reduce their sugar intake.

            •Artificial sweeteners are made from natural sources (e.g., Stevia) – their significantly higher sweetness makes them an appealing choice for individuals concerned about weight, diagnosed with diabetes, or having other medical requirements. This is due to their nearly negligible calorie content.

            •Lessen calorie consumption – when most artificial sweeteners contain zero calories, they do not contribute to the risk of exceeding calorie intake.

            •Convenient – they are suitable for use in various products such as candies, baked goods, jams, jellies, dairy items, and carbonated beverages, particularly in baking, canning, and packaging.

            •Enhancing oral health – excessive sugar consumption often leads to tooth decay. Sugar accumulation on teeth is associated with promoting bacterial growth and resulting in oral health issues. Unlike sugar, artificial sweeteners do not interact with oral bacteria and thus do not produce acids or contribute to tooth decay.

Disadvantages of Artificial Sweeteners

            However, the disadvantages of artificial sweeteners are presented as discussed by Regoli (5), namely

            •Undesirable aftertaste – while certain artificial sweeteners can enhance the taste of food and beverages, others can leave behind a sour aftertaste when consumed. This aftertaste can be distinctly unpleasant for certain people, which may require either using a combination of artificial sweeteners or opting for alternative products to achieve desired taste and calorie goals.

            •Opting for artificial sweeteners means substituting sugars with chemical compounds (Stevia is excluded) – the sugar found in products containing artificial sweeteners is chemically derived rather than a natural substance. Some experts suggest that this poses an elevated risk of diseases, including cancer, and could potentially lead to neurological issues or increased cholesterol levels by altering the liver’s ability to process fats. Numerous studies indicate that regular consumption of artificial sweeteners can also intensify cravings for other sweet foods.

            •Potential Weight Gains – even though artificial sweeteners contain no calories, they can lead individuals to associate sweetness with the number of calories consumed daily. Consuming artificial sweeteners can stimulate cravings for other sweet foods. When the body is not receiving sufficient nutrients, it may continuously seek more food, resulting in solid desires for high-calorie, sugary items. Aspartame, acesulfame-K, and saccharin have been linked to increased food consumption, with aspartame having the most potent effect on appetite. Artificial sweeteners can create cravings for sweetened foods, and reducing dependence on sugar or artificial sweeteners is recommended (6).

Potential Long-term Health Effects (6)

            Impact on Gut Health – while not absorbed by the body, non-caloric artificial sweeteners can still affect the gut microbiota (microorganisms in the human gastrointestinal tract), potentially leading to metabolic syndrome. In a study with mice, saccharin, sucralose, or aspartame consumption resulted in glucose intolerance due to changes in gut microbiota caused by saccharin.

            Cancer – early animal studies suggested a link between cyclamate, saccharin combination, and cancer. However, FDA studies found no association between these artificial sweeteners and human cancer. Other FDA-approved sweeteners also showed no evidence of a connection to various types of cancer.

            Diabetes – non-nutritive sweeteners have minimal calories and require only a tiny amount of sweetness. However, excessive consumption of foods with artificial sweeteners can impact glucose metabolism, leading to weight gain and health complications like type 2 diabetes.

            Headaches – some individuals may experience headaches triggered by aspartame or sucralose. Prolonged use of sweeteners in diet beverages appears to have a more vital link to migraines.

             It is important to note that sugar and natural sweeteners contribute to various health issues, such as hypertension, inflammation, type 2 diabetes, and much more (1). Artificial sweeteners are also linked to harmful health effects, as mentioned above. Consumers must consider their intake carefully, and the public health sectors should also aim to promote nutrition literacy as well.


1.Harvard Health Publishing. (2022). The sweet danger of sugar. Retrieved June 27, 2023, from

2.Harvard School of Public Health. (2023). Low-Calorie Sweeteners. Retrieved June 27, 2023, from

3.Jain, S. (2023). Pros and Cons of Artificial Sweeteners Explained. Retrieved June 27, 2023, from

4.National Cancer Institute. (2023). Artificial Sweeteners and Cancer. Retrieved June 27, 2023, from

5.Regoli, N. (2019). 18 Advantages and Disadvantages of Artificial Sweeteners. Retrieved June 27, 2023, from

6.Schiller, R. (2021). The Pros and Cons of Artificial Sweeteners. Retrieved June 27, 2023, from

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